Review mOAT

[Rebecca Carey]

Dr Woeller
Attached is mOAT that I ran on a teenager with gastroparesis and SIBO who did not improve with antibiotics for SIBO and is not responding to pro motility agents. There is some concern she may have a mitochondrial disorder as her older sister does. I ran this to see if there was a yeast issue. Can you look at as it seems the main elevation was tartaric acid and I know you mentioned that you sometimes see that in Chronic fatigue but that is can also be toxic to muscles which may explain some of her gastroparesis??? Thanks much

[DrWoeller]

Rebecca,
My suspicion would be the Tartaric may be coming from an food preservative, especially since the Arabinose is normal.

The clostridia markers are high normal, but overall not much to go on from a GI pathogen effect.

BTW – the tartaric, whether from food or yeast, could still have a toxic effect throughout the body.

Have you done any type of Mitochondria testing?

Sincerely,
Dr. Woeller

[Rebecca Carey]

She sees a metabolic specialist so I have left the mt testing to them. However are you referring to muscle biopsy or blood/urine analysis?

[Rebecca Carey]

I have attached another OAT. This one is from 2014. This patient had very mild abdominal pain and nausea and is a picky eater. I was struck by how high the arabinose is and what few symptoms the patient had. Can you comment on this. Also what is the specificity and sensitivity of the arabinose is detecting yeast? i.e. what is false negative and false positive rate?
thanks

[DrWoeller]

Rebecca,
False positives can come about from eating foods around the time of collection namely apples. This list is given within the collection instructions. Other than that there are not false positives that I know of. However, there are outliers of patients that don’t manifest with a lot of symptoms. Mostly, these are rare.

Dr. Woeller

P.S. Oxalates where high though which can come from yeast and diet

[DrWoeller]

Also, to you last question.

I am talking about blood and urine analysis. To get a confirmation of mitochondrial disease from my understanding a biopsy is needed.

Dr. Woeller

[Rebecca Carey]

so for the high arabinose on the OAT if you confirm no dietary contaminant how would you treat? Which protocol would you use with a very high arabinose level but mild symptoms? The mild protocol?

Would you expect the oxalate levels to come down with treatment if from yeast and you have reviewed the diet and don’t see any high oxalate foods? What interval do you use to retest?

thanks!

[DrWoeller]

Rebecca,
I would retest in 90 days, and would use the Moderate protocol. I think this type of patient could handle something a little more aggressive.

Dr. Woeller

[Author]

Posts