Q: As an alternative to a compounding pharmacist for those with some histamine sensitivity, do you have any experience wtih Daosin – diamine oxidase (DAO) – since it’s readily available and thought to also reduce histamine action, expecially of foods.
In a few people. The results are mixed, but there is a lot at play with histamine, i.e. other allergies, histamine load.
There is some research that show DAO may help with migranes – http://www.sciencedirect.com/science/article/pii/S0022510X13020984. According to this paper approximately 87% of people with migranes suffer from decline in DAO activity. They used a DAO supplement with 4.2mg of DAO, and even though there wasn’t significant inhibition of migraine, the length of an attack was reduced.
I think DAO is worth a try, but more of it may be needed in addition to people regulating their diet.
Testing for polymorphisms may help to identify people who are more susceptible to histamine issues too.